Funct. Mater. 2019; 26 (4): 664-672.
Inclusion complexes of melatonin and randomly methylated β-cyclodextrin: spectroscopic study
Institute for Scintillation Materials, STC "Institute for Single Crystals", National Academy of Sciences of Ukraine, 60 Nauky Ave., 61072 Kharkiv, Ukraine
In this research host-guest complex formation of melatonin (MT) with randomly methylated β-cyclodextrin (RMβCD) in aqueous solutions and in solid state has been investigated by differential scanning calorimetry, Fourier transform infrared spectroscopy analysis, fluorescence and ultraviolet-visible absorption spectroscopy and phase solubility measurements. The phase solubility data indicate a linear increase in the solubility of MT with RMβCD pointing to the Higuchi's AL-type phase solubility profile. According to the continuous variation Job's method applied to spectroscopy measurements, a 1:1 stoichiometry has been proposed for the complex formed. Stability constants for the RMβCD/MT inclusion complexes have been calculated by fluorescence spectroscopy using the Benesi-Hildebrand method, while the thermodynamic parameters have been estimated using the Van't Hoff equation. The data obtained indicate that the binding process of RMβCD with MT is exothermic and enthalpy-driven. The superiority of the RMβCD/MT inclusion complex in photostability has been revealed.
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