Funct. Mater. 2020; 27 (1): 184-191.
Synthesis, characterization and antimicrobial properties of chemically modified apatite-related calcium phosphates
1T. Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., 01601 Kyiv, Ukraine 2Zabolotny Institute of Microbiology and Virology National Academy of Science of Ukraine, 154 Zabolotnogo Str., 03143 Kyiv, Ukraine
Na+, CO32--HAPs and Na+, M2+, CO32--HAPs (M2+ - Zn2+, Cu2+) were synthesized by precipitation method and characterized. According to powder XRD and SEM data the prepared particles of all samples are of nano size and single phase. The quantitative elemental analysis showed that obtained calcium phosphates contain the following substituted elements: Na+ (0.2-0.3 %wt), Zn2+ (1.1 %w/w) or Cu2+ (1.9 %wt) and CO32- while the FTIR data confirm the partial substitution of phosphate by carbonate group (B-type) in HAP structure. The influence of particles size on phosphates properties was also determined for sample Na+, CO32--HAP heated to 700°C. The antimicrobial properties of synthesized nanoparticles of chemically modified calcium phosphates against of opportunistic microorganisms - Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pyogenes were studied. The antimicrobial effect of modified HAPs (5-20 mM) on all tested reference strains was established. Prepared Na+, Zn2+, CO32--HAP had higher inhibitory activity against Gram-positive microorganisms - S. aureus and S. pyogenes than that for Gram-negative ones. Phosphate Na+, Cu2+, CO32--HAP had strong inhibitory effect on both Gram-positive and Gram-negative bacteria.
1. J.Lu, H.Yu, C.Chen, RSC Adv., 8, 2015 (2018). https://doi.org/10.1039/C7RA11278E |
||||
2. K.Ishikawa, Y.Miyamoto, A.Tsuchiya et al., Materials, 11, 1993 (2018). https://doi.org/10.3390/ma11101993 |
||||
3. J.Enax, M.Epple, Oral Health &Preventive Dentistry, 16, 7 (2018). | ||||
4. A.Amedlous, O.Amadinea, Y.Essamlalia et al., RSC Adv., 9, 14132 (2019). https://doi.org/10.1039/C9RA02021G |
||||
5. M.Schiavoni, S.Campisi, P.Carniti et al., Appl. Catalysis A: General, 563, 43 (2018). https://doi.org/10.1016/j.apcata.2018.06.020 |
||||
6. C.Rosticher, B.Viana, T.Maldiney et al., J. Luminescence, 170, 460 (2016). https://doi.org/10.1016/j.jlumin.2015.07.024 |
||||
7. M.A. Pogosova, A.A.Eliseev, P.E.Kazin et al., Dyes and Pigments, 141, 209 (2017). https://doi.org/10.1016/j.dyepig.2017.02.029 |
||||
8. S.L.Iconaru, M.Motelica-Heino, R.Guegan et al., Materials, 11, 2204 (2018). https://doi.org/10.3390/ma11112204 |
||||
9. M.Ferri, S.Campisi, M.Scavini et al., Appl. Surf. Sci., 475, 397 (2019). https://doi.org/10.1016/j.apsusc.2018.12.264 |
||||
10. C.Huang, S.Bhagia, N.Hao et al., RSC Adv., 9, 5786 (2019). https://doi.org/10.1039/C8RA09523J |
||||
11. A.A.Hendi, J. All. Comp., 712, 147 (2017). https://doi.org/10.1016/j.jallcom.2017.04.021 |
||||
12. P.Choudhury, D.C.Agrawal, Surf. Coat. Techn., 206, 360 (2011). https://doi.org/10.1016/j.surfcoat.2011.07.031 |
||||
13. A.Bigi, E.Boanini, M.Gazzano, Fundam. Applic., 235 (2016). https://doi.org/10.1016/B978-1-78242-338-6.00008-9 |
||||
14. H.Madupalli, B.Pavan, M.M.J.Tecklenburg, J. Solid State Chem. 255, 27 (2017). https://doi.org/10.1016/j.jssc.2017.07.025 |
||||
15. E.Garskaite, K.-A.Gross, S.-W.Yang et al., Cryst. Eng. Comm, 16, 3950 (2014). https://doi.org/10.1039/c4ce00119b |
||||
16. Y.Huang, X.Zhang, H.Mao et al., RSC Adv., 5, 17076 (2015). https://doi.org/10.1039/C4RA12118J |
||||
17. D.V.Shepherd, K.Kauppinen, R.A.Brooks et al., J. Biomed. Mater. Res. Part A, 102A, 4136 (2014). https://doi.org/10.1002/jbm.a.35089 |
||||
18. V.Stanic, S.Dimitrijevic, J.Anti'c-Stankovic et al., Appl. Surf. Sci., 256, 6083 (2010). https://doi.org/10.1016/j.apsusc.2010.03.124 |
||||
19. E.S.Thian, T.Konishi, Y.Kawanobe et al., J. Mater. Sci: Mater. Med., 24, 437(2013). https://doi.org/10.1007/s10856-012-4817-x |
||||
20. Z.Gang, L.Yubao, X.Wei et al., J. Biomedical Mater. Res. Part A, 930 (2007). | ||||
21. N. Strutynska, I.Zatovsky, N.Slobodyanik et al., Europ. J. Inorg. Chem., 2015, 622 (2015). https://doi.org/10.1002/ejic.201402761 |
||||
22. G.T.Feitosa, M.V.Santos, H.M.Barreto et al., Mater. Sci. Forum, 869, 890 (2016) https://doi.org/10.4028/www.scientific.net/MSF.869.890 |
||||
23. D.Predoi, C.L.Popa, P.Chapon et al., Materials 9, 778 (2016). https://doi.org/10.3390/ma9090778 |
||||
24. C.Valgas, S.M.Souza, E.F.A.Smўnia et al., Braz. J. Microbiol, 38, 369 (2007). https://doi.org/10.1590/S1517-83822007000200034 |
||||
25. S.Sathiskumar, S.Vanaraj, D.Sabarinathan et al., Mater.Res. Express, 5, 2 (2018). https://doi.org/10.1088/2053-1591/aaae10 |
||||
26. G.D.Venkatasubbu, S.Ramasamy, V.Ramakrishnan et al., Biotech., 1, 173 (2011). https://doi.org/10.1007/s13205-011-0021-9 |
||||
27. J.Pasquet, Y.Chevalier, J.Pelletier et al., Colloid. Surface A., 457, 263 (2014). https://doi.org/10.1016/j.colsurfa.2014.05.057 |
||||
28. X.Wang, A.Ito, Y.Sogo et al., Acta Biomater., 6, 962 (2010). https://doi.org/10.1016/j.actbio.2009.08.038 |
||||
29. H.Yang, L.Zhang, K.-W.Xu, Ceram. Internat., 35, 1595 (2009). https://doi.org/10.1016/j.ceramint.2008.09.012 |
||||
30. D.Osman, K.J.Waldron, H.Denton et al., J. Biological Chem., 285, 25259 (2010). https://doi.org/10.1074/jbc.M110.145953 |
||||
31. O.Soutourina, S.Dubrac, O.Poupel et al., PLoS Pathogens, 6, 1000894 (2010). https://doi.org/10.1371/journal.ppat.1000894 |