Funct. Mater. 2020; 27 (2): 390-395.
Preparation and photostability of homosalate with 2-hydroxypropyl-β-cyclodextrin inclusion complex
1Central Research Institution of Building and Construction Co., Ltd., 100088 Beijing, China
2China Jingye Engineering Technology Co., Ltd., 100088 Beijing, China
3Beijing Industrial Building Construction Materials Engineering Technology Research Center, 100088 Beijing, China
Homosalate (HMS) is widely used as the UVB-filter with the disadvantage of poor water solubility and low photostability. In this study, the inclusion complex of HMS with 2-hydroxypr opyl-β-cyclodextrin (HP-β-CD) was prepared by the freeze-drying method. The UV-Vis study indicated that HMS can form an inclusion complex with HP-β-CD in a stoichiometric ratio of 1:2. Thermogravimetric (TG), differential scanning calorimetry (DSC), scanning electron microscope (SEM) and nuclear magnetic resonance (1H NMR) also demonstrated that HMS was successfully encapsulated by HP-β-CD. Meanwhile, the water solubility and thermal stability of HMS was obviously improved after the formation of the inclusion complex. Furthermore, the photolysis ratio of the HMS-HP-β-CD inclusion complex decreased from 21.4 % to 7.9 %.
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