Funct. Mater. 2021; 28 (4): 628-632
Functional nanoparticles for biomedical applications: a dsc study of membranotropic behavior
1Institute for Scintillation Materials, STC "Institute for Single Crystals" National Academy of Sciences of Ukraine, 60 Nauky Ave., 61001 Kharkiv, Ukraine
2Taras Shevchenko Kyiv National University, Kyiv, Ukraine
3National University of Kyiv-Mohyla Academy, Kyiv, Ukraine
Interaction of fullerene-containing silica nanoparticles (SiO2-C60, SiO2-C60-Pd) and DNA of natural origin (DNA and low molecular weight DNA - LmwDNA) with phospholipid model membranes was studied using differential scanning calorimetry (DSC). SiO2-C60, SiO2-C60-Pd and DNA had only minor effects on L-α-dipalmitoyl phosphatidyl choline (DPPC) membrane phase transitions, remaining essentially inert. LmwDNA induced noticeable changes in the DSC profiles, with the effects (increasing of the main phase transition temperature, significant peak broadening and splitting, vanishing of the pre-transition peak) increasing with concentration. No noticeable deviations from additivity could be noted under joint introduction of the nanosystems into DPPC membranes.
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