Funct. Mater. 2025; 32 (2): 266-271.
Peculiarities of influence of anionic modification on formation of Na+, Mg2+, Zn2+-containing calcium phosphates
1 Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64/13, 01601 Kyiv, Ukraine
2Enamine Ltd, 78 Winston Churchill Str., 02094, Kyiv, Ukraine
The paper presents a study of the effect of adding carbonate or borate anions to the initial solution of the Ca2+-Mg2+-Zn2+-Na+-PO43- system on the formation of calcium phosphates containing Na+, Mg2+, Zn2+. In the Сa2+-Mg2+-Zn2+-Na+-PO43- system, the biphasic calcium phosphates (mixture of phases based on Са10(РО4)6(ОН)2 and β-Са3(РО4)2) have been obtained. It was established that an increase in the amount of Zn2+ in the initial solution leads to an increase in the content of phase β-Са3(РО4)2 from 25wt% to 75wt% in biphasic calcium phosphates and its particles size from 35 to 71 nm. In vitro tests of the modified calcium phosphates with different anionic composition in model solution at 37°C showed the highest activity: an increase in pH more than 35% after first 48 hours and for 14 days of the study for calcium carbonate apatite phosphate containing Na+(0,5wt%), Mg2+ (0.5wt%) and Zn2+(1.7wt%). At the same time, borate-containing phosphate with a similar content of trace elements showed activity only during first 48 hours with a pH change of 20%. Obtained results showed the possibility of obtaining apatite-related modified calcium phosphate with different dissolution rates by changing the nature of anionic dopant when designing materials for orthopedics.
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